30–31 May 2024
Wigner Datacenter - HUN-REN Wigner Research Centre for Physics
Europe/Budapest timezone

Image reconstruction with proton computed tomography

31 May 2024, 16:35
25m
Wigner Datacenter - HUN-REN Wigner Research Centre for Physics

Wigner Datacenter - HUN-REN Wigner Research Centre for Physics

HUN-REN Wigner RCP 1121 Budapest, Konkoly-Thege Miklós rd 29-33, Hungary

Speaker

Ms Zsófia Jólesz (Wigner Research Centre for Physics)

Description

One of the most successful treatments in cancer therapy is proton therapy, with radiation planning being a key element. Photon CT is commonly used for this purpose; however, it does not provide sufficiently accurate information about the range of protons. Therefore, proton CT imaging is more favorable for radiation planning. Due to the Coulomb scattering of protons, it is important to calculate the Relative Stopping Power at the voxel level (thus, appropriate handling of trajectories is also required), for which several algorithms have been developed. The aim of my research is to test, further develop, and optimize a software package using the Richardson-Lucy algorithm developed in the Bergen Proton-CT Collaboration.

The simulations necessary for the research were performed using the Geant4 and Gate software. I optimized the framework using the Richardson-Lucy algorithm with appropriate methods for faster and more efficient operation. I verified the operation of the algorithm and image reconstruction on phantoms developed to measure the performance of medical imaging systems at different energies.

During my work, I managed to optimize the algorithm, significantly reducing the runtime. Based on the evaluation of phantom reconstruction, I found that the algorithm operates with the desired accuracy.

Among my long-term goals are further optimization and achieving clinical usability (including further reducing runtime).

Primary author

Ms Zsófia Jólesz (Wigner Research Centre for Physics)

Presentation materials